Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity
Genome rearrangements, a hallmark of cancer, can result in gene fusions with oncogenic properties.Using DNA paired-end-tag (DNA-PET) whole-genome sequencing, we analyzed 15 gastric cancers (GCs) from Southeast Asians.Rearrangements were enriched in open chromatin and shaped by chromatin structure.We identified seven rearrangement hot spots and 136